In my case, I have a two, identical, heavily modified laptops, with i7 processors, 32Gb Ram, and 12Tb of SSD internal storage (2 x 4TB Samsung 870 EVO and 1 x Samsung 990 PRO M.2) each. When I run a show, both laptops are run side by side, in case of failure of the laptop I am using at the time. Both laptops have fully licensed copies of both Karma and VIrtual DJ running on them, and the laptops and the digital mixer are connected to an APC Smart-UPS during shows.
The 990's are configured with a 1Tb System partition, and a 3Tb partition for Karaoke tracks, currently holding 251,000 individual tracks, with 95,215 distinct songs, many obviously with multiple versions by diffrent producers.
One of the 870's has a single 4Tb partition exclusively containing my music media, running into about 4.2Tb of tracks, covering a wide range of genres and eras. I keep my audio files mainly by Artist, except in the case of some specific labels, such as Atlantic, Motown, Trojan, Philly, Solar, Stax-Volt etc. as well as compilation labes like NOW, MOS, Hed Kandi, etc. There are distinct folders for Mastermix and CD Pool, as well as a few specific genres such as Northern Soul, Lovers Rock, Movie and Show OST. 50's/60's Rock and Roll, Irish, etc. where the number of albums warrant the separation. In addition, I have a Charts section that has Top 40's, buth current, and annually I break out the No. 1's and sum the tracks for each year.
The other 870 is populated with Music Videos. These are split up into folders such as Decades, Producers such as Promo Only, etc. as well as Charts, and once again specific Genres, such as DanceHall/Reggaeton, Hip-Hop/RnB, Rock, Swing, Disco, Reggae etc. I currently have just under 104k of videos, but these are updated frequently.
The two laptops are mirrored and synch'd automatically from a master drive array on my primary PC, which also acts as a backup and storage facility that I link to in case of emergencies when running shows, using a 5G mobile router and VPN. This also allows me to download tracks that are requested but not in my collection from the likes of Zoom, Mr Entertainer, Karaoke Version etc. and are automatically added to my laptops and Master storage at point of download.
This is obviously just the way I organise my laptops and drives, I am sure there are many other ways to do it, but this is the system I have developed over time since going digital!